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Supplement for Bone Health


Supplement for Bone Health

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  • Bone Topics
  • Supplement Comparison

Need help deciding which Osteo-K is right for you? Read the Osteo-K Comparison Page.
Osteo-K contains a 45 mg of MK4™, also called MK-4™, menaquinone-4 and menatetrenone. MK4 is a form of Vitamin K2. The Archives of Internal Medicine confirms that 45 mg of MK4™ daily can decrease the risk of vertebral fractures by 60%, hip fractures by 71% and all nonvertebral fractures by 81%.

SAFETY: From a large number of clinical trials using dosages in excess of 40 mg/day, there were no reports of side effects associated with any type of hypercoagulable (increased blood clotting) state. Both animal and clinical studies support the conclusion that MK4 has no dangerous effects on blood clotting. More than 6,000 people (view table summarizing these studies) with AML, MDS, osteoporosis, Parkinson disease, Alzheimer disease, hepatocellular carcinoma, liver failure, liver cirrhosis, myelofibrosis and kidney failure on hemodialysis have taken 45 mg daily (and higher doses) of MK4 for up to eight years without any serious side effects. However, it should be noted that the anticoagulant effect of warfarin, functioning by its interference with the clotting effect of vitamin K, can be offset with as little as 1 mg of vitamin K. If you are on anticoagulant therapy (e.g., taking warfarin), you should not take Osteo-K or Osteo-K Minis. For everyone else, Osteo-K and Osteo-K Minis are safe.
Calcium and vitamin D decrease how fast people lose bone minerals; however, MK4 in the amounts found in Osteo-K and Osteo-K Minis have been shown to actually increase bone mineral density and decrease fracture risk.

Don't be fooled by other bone health formulas that contain vitamin K. Only Osteo-K contains the amount and form used in clinical trials--45 milligrams (nearly all other formulas contain much smaller amounts, measured in micrograms, which can be hundreds of times less than what's in Osteo-K). And other products contain MK7, another form of vitamin K, but which has never been shown in clinical trials to reduce fractures. Only MK4 reduces fractures. MK4 (45 mg daily) is so effective that it's been an approved by the Ministry of Health in Japan since 1995 for the treatment of osteoporosis.

MK4 (45 mg/d) alone and in combination with vitamin D3 and calcium matches or exceeds the benefits in clinical trials of Fosamax, Actonel and Boniva without the dangerous side effects.

MK4 exerts a powerful influence on promoting bone health and is one of the most frequently prescribed nutrients in Japan for growing strong bones and decreasing fractures. MK4 is a fat soluble vitamin that is a coenzyme for a vitamin K-dependent carboxylase enzyme catalyzing the carboxylation of the amino acid, glutamic acid, resulting in its conversion to gamma-carboxyglutamic acid (Gla).

Although vitamin K-dependent gamma-carboxylation occurs only on specific glutamic acid residues in a small number of proteins, it is critical to the calcium-binding function of those proteins. Three vitamin-K dependent proteins have been isolated in bone. Osteocalcin is a protein synthesized by osteoblasts (bone forming cells). The synthesis of osteocalcin by osteoblasts is regulated by the active form of vitamin D, 1,25(OH)2D3 or calcitriol. The mineral-binding capacity of osteocalcin requires vitamin K-dependent gamma-carboxylation of three glutamic acid residues.

Matrix Gla protein (MGP) has been found in bone, cartilage, and soft tissue, including blood vessels. The results of animal studies suggest MGP prevents the calcification of soft tissue and cartilage, while facilitating normal bone growth and development.

Vitamin D3, the active form of vitamin D, is involved in many physiological processes. It increases calcium absorption, and has been shown in clinical trials alone and in combination with MK4 and calcium, to reduce fracture risk in osteoporosis.

Calcium is essential for bones and teeth, heart, nerves, muscles, and blood clotting. About 99% of the calcium in the body is found in bones and teeth, while the other 1% is found in the blood and soft tissue. Calcium supplementation has been shown in clinical trials to increase bone mineral density. Providing supplemental calcium is the standard of care for people with low bone mineral density.

Directions: Take three capsules twice daily with food.

References
More than 100 citations support the ingredients in Osteo-K for bone health, cardiovascular health and cancer support.





In October of 2008, I was diagnosed with having borderline osteoporosis. I didn't want to take prescription drugs and found Dr. Neustadt who suggested Osteo-K. This past May, 2010, I had another bone scan and learned my bone density had increased 6% which my doctor said was statistically significant. I'm elated and want more women to know about this. It's possible to treat our bones with no side effects!

—Ris, Bozeman, MT

Am very pleased with this product--improved results on my bone density scan!

—Margarete, Marana, AZ

About three years ago, I was diagnosed with osteoporosis with a 7% bone loss. I was prescribed Fosamax and oral calcium supplements and took both for several months. When I had my second bone scan, I was worse. I read about Osteo-K in Bottom Line and ordered my first bottle. The results over the past few months have been good for me. I have fingernails past the ends of my fingers for the first time in my life and can't wait for my next scan to see the improvements to my bones! Thank you NBI!!!

—Karen, Mesa, AZ.

I was still working full time as an accountant at age 70, but it was becoming painful to bend down or even stand for short periods of time.

My doctor did a bone density scan and I was diagnosed with severe osteoporosis.  He prescribed Boniva immediately and I tried it.  I have never experienced as much pain in every part of my body as that one pill caused.  When I complained to my doctor he said that he believed that one day of pain was worth the results Boniva could attain.  I tried it once more and said never again!

In Bottom Line I read about Osteo-K and the research that had been done by the prestigious doctors that had formulated it.  I decided to try it. 

I have been taking Osteo-K for 8 months now and have an automatic order for it so that I never run out.  I was able to discontinue 3 other supplements I was taking because they were included in Osteo-K.

Strength has returned to my legs, my back, and even my neck.  I feel better than I did 10 years ago.  And what I consider to be a great side benefit is that my fingernails now grow fast, hard and clear.  That is something that I always wished for, but never had.

Everyone should know about this wonderful product!

—Arlene, Elk Grove Village, IL

Osteo-K increased bone mineral density better than Fosamax in a much shorter time.

—Karen

I've been using Osteo-K for two or three months now. I don't recall in which publication I first read about the product. I've had one total hip replacement and one that probably should be replaced. Since using Osteo-K there seems to be much less pain in this and other joints even though this was not the primary reason for taking Osteo-K. Previously I was taking Actonel for osteoporosis and thin bones.

—John

I started using Osteo-K about eight months ago, in June 2009. Before using Osteo-K, I was experiencing extremely painful joints and was using several pain medications and thought I might end up in a wheel chair. I needed pain medications just to sleep at night. My rheumatologist prescribed alendronate (Fosamax) to increase my bone density.

After reading about Osteo-K and hearing and reading about various horror stories about Fosamax, I decided to 'fire' my rheumatologist and stopped taking the Fosamax and instead bought 13 bottles of Osteo-K 'to try.' In a matter of weeks after starting the Osteo-K, I experienced remarkable relief from the majority of symptoms, especially the hip and knee pain. I am scheduled to go in for my next bone density test around July of 2010. I believe that this test will validate everything I personally believe to be true about Osteo-K.

—Rosemary, Cottrellville Twp., MI

I was thrilled to get the results of my recent bone density scan, which showed definite improvement in bone minerals in both my back and hip.I just turned 52 years old and have a small frame. Osteoporosis runs in my family. I am a healthy eater,exercise regularly and vigorously, and do not smoke. I am allergic to dairy products so I get calcium from supplements.

Because I know I am prone to this condition and try to "do all the right things" I was somewhat surprised that my traditional physician diagnosed osteoporosis when I got my baseline DEXA scan two years ago at age 50. When I received this diagnosis I consulted you and sent you the test results to review. Weekly Actonel had been prescribed. You suggested that I supplement the Actonel with Osteo-K, which you had developed.

I have followed a regimen of daily Osteo-K and weekly Actonel for two years and will discuss alleviating the Actonel with my traditional physician. I intend to continue using Osteo-K and look forward to evidence of further improved bone minerals in my next bone density scan two years from now.
Thank you for conceiving this product. It's important and it works!

—Karen, McClean, VA


I wanted to let you know that a recent bone density came back surprisingly well.  My doctor called it a "robust" result in fact.  My AP Spine (L1-L4) had a BMD change of 12.7 vs previous result.

I believe these results changed because I began Osteo K about 3 months ago.  I was taking Fosamax for 7 years and had changed over to Boniva this past year with minimal change until I added the Osteo K supplement.  My results had not been like this since '03! I thought you would be excited to know.

—Karen, Westford, MA


I was placed on Boniva in Sept.2008. It always bothered my stomach. I persevered with it but started getting pains in my joints, legs neck hands and wrists, and knees. My exercise program disappeared as I became weaker. My knees had to be drained Three times because fluid had built up to such an extent walking was a problem. I spoke to the doctor about stopping the Boniva since I was in great health before starting it! He didn't feel it was a problem. I went home and began a search for help online. It was there I found Save Our Bones, Dr. Neustadt and Osteo-K. In three months my health has gone back to pre Boniva days. That drug was truly poison for me. Thanks so much for the research that you have done and the great alternatives you offer to keep us in better health than many of the highly advertised drugs that are pushed so hard by drug companies and many doctors. Osteo K has become my body's best friend! You may share my story. I hope many women find their way to you.

—Alice, Point Pleasant Beach, NJ


I have been a board certified Gynecologist and Obstetrician for more than twenty years. As a clinical instructor for Obstetrics and Gynecology at John's Hopkins University, I trained medical students. One of the most dangerous conditions I repeatedly encountered was osteoporosis. 

Osteoporosis has reached epidemic proportions all over the world. It's clear from my experience and the literature that osteoporosis increases the risk of major disabilities and early death. People with osteoporosis, or those who are at risk for osteoporosis, need to be proactive in protecting and improving the health of their bones.

I reviewed the research on the health effects of 45 mg/day of MK4. I am extremely impressed with MK4's ability to decrease fracture risk by up to 81%; better than any osteoporosis medication I have ever prescribed. I recommend my patients take Osteo-K to protect their bones and prevent fractures. I also encourage other physicians to use Osteo-K.

—Mick Lifson, MD, voted "Baltimore's Best Gynecologist" by Baltimore Magazine in 2002 and 2007.


I was diagnosed with gluten intolerance three years ago, after suffering for nearly fifty years with gut symptoms, migraine headaches, joint pain and skin rashes. Over the last ten years I developed severe, debilitating bone pain in my spine and pelvis associated with osteoporosis. Every time I tried to stretch or exercise my pain increased. I felt inflamed all the time.

Bone pain associated with bone loss due to malabsorption is a symptom commonly associated with gluten intolerance. After researching the health benefits and bone-building effects of MK4, a form of vitamin K, I started taking Osteo-K. MK4 is a non-soy based form of vitamin K shown to build bone and decrease fracture risk. Three days after beginning Osteo-K my bone pain began to improve. After three months of Osteo-K my bone pain is gone and I am able to gently exercise and stretch without spine or pelvic pain afterwards!

I recommended Osteo-K to another woman suffering from gluten-intolerance with osteoporosis and pelvic bone pain. After taking Osteo-K for one month she reports a 70% improvement in her bone pain. She also told me that she is now taking a weekly dance class and having no pain afterwards.

One of the most common findings of gluten intolerance is loss of bone, even in children. Prevention is always so much simpler than treating disease. Osteo-K is one more tool to help prevent the development of osteoporosis from malabsorption. Children who are diagnosed with gluten intolerance would benefit from taking Osteo-K, along with a gluten free diet,  to improve bone-building while they are growing. If you already have osteoporosis, Osteo-K can dramatically decrease your pain and risk of fractures.

—Eve Cohn, DC, MS, Norman, OK

Following a traumatic hemorrhage which filled my lungs and nearly destroyed my life, my condition was diagnosed as mylodysplasia. This was a disease which caused my bones to stop producing normal amounts of blood platelets, the clotting factor that prevents uncontrolled bleeding. My doctor said there was no known cure for this disease and did not expect me to survive.

The hospital chaplains gathered in my room to help prepare me and my family for my imminent death. By the grace of God, I did not die, but continued to survive for nine weeks in the hospital before they sent me home to die.           

In spite of the prognosis, I continued to live in this critical condition for two years. My survival depended on a schedule of three blood platelet infusions a week and countless blood transfusions. I endured chemo therapy, experimental drug therapy, frequent hemorrhages, agonizing pain and nausea which weakened me to the point of having to use a wheel chair. Obviously, I was unable to keep my job.

Eventually, I decided to take responsibility for my own health and through my research, discovered that vitamin K provided a coagulating factor. When I asked my doctor about vitamin K, he said it would not help my condition. I made the decision to try it on my own. When I started taking vitamin K in low dosage amounts of 1,000 mcg, the number of weekly infusions decreased from three to two.  This encouraged me to gradually increase the dosage of vitamin K to 5,000 mcg. As the dosage increased so did the time between infusions.

My most significant breakthrough came when I discovered Osteo-K Bone Support in 45,000 mcg. This nutritional product was so effective that I was able to stop all platelet infusions and blood transfusions.

As I write this account of my medical experience, I live a very normal life with renewed energy and actually go dancing every week. Osteo-K has restored my life.

—Paula Etrick, Longmont, CO

I am seventy-eight years old and grew up in Butte, Montana being active with my children, my husband's business and my community. I have seven grandchildren now and three live near me. I want to stay healthy to be able to do things with them and continue to drive my car and live independently. I have severe osteoporosis. Four years ago I fell and broke my hip and leg, then one year later I fell and broke my shoulder and arm. I had to have surgery to repair my leg, and underwent a long, painful recovery. Two years ago I discovered Osteo-K. I've taken Osteo-K every day now since then. I have fallen two more times while taking Osteo-K, but I didn't break any bones. The doctors were completely surprised. I give Osteo-K all the credit. Thank you for saving my bones and my life.

—Dolores, Bozeman, MT

 

Research Citations for Ingredients in Osteo-K

NBI's research and development team—led by physicians from Harvard, Cornell, MIT and Bastyr—is obsessed with researching NBI product ingredients. Before NBI manufactures a product the formula must first pass rigorous tests to ensure its ingredients are strongly supported by published research from around the world. The amount of resources dedicated to investigating NBI product ingredients, and the quality of research, are considered the highest in the industry.

There are more than 100 research studies supporting the ingredients in Osteo-K and Osteo-K Minis. This page lists the studies done on Osteo-K and Osteo-K Minis' ingredients for bone and cardiovascular health. You can also click to see tables summarizing the MK4 research for cancer support.

Learn why Osteo-K clobbers the competition: click to view a chart comparing Osteo-K to other leading calcium supplements, such as Viactiv, Citracal, Bone-Up, Os-Cal and Caltrate.

MK4 and Bone Mineral Density

  1. Adams J, Pepping J. Vitamin K in the treatment and prevention of osteoporosis and arterial calcification. Am J Health Syst Pharm. 2005;62(15):1574-1581.
  2. Hara K, Kobayashi M, Akiyama Y. Vitamin K2 (menatetrenone) inhibits bone loss induced by prednisolone partly through enhancement of bone formation in rats. Bone. Nov 2002;31(5):575-581.
  3. Iketani T, Kiriike N, B. Stein M, et al. Effect of menatetrenone (vitamin K2) treatment on bone loss in patients with anorexia nervosa. Psychiatry Research. 2003;117(3):259-269.
  4. Inoue T, Sugiyama T, Matsubara T, et al. Inverse correlation between the changes of lumbar bone mineral density and serum undercarboxylated osteocalcin after vitamin K2 (menatetrenone) treatment in children treated with glucocorticoid and alfacalcidol. Endocr J 2001;48:11-18.
  5. Iwamoto I, Kosha S, Noguchi S, et al. A longitudinal study of the effect of vitamin K2 on bone mineral density in postmenopausal women a comparative study with vitamin D3 and estrogen-progestin therapy. Maturitas 1999;31:161-164.
  6. Iwamoto J, Takeda T, Ichimura S. Combined treatment with vitamin K2 and bisphosphonate in postmenopausal women with osteoporosis. Yonsei Med J 2003;44:751-756.
  7. Iwamoto J, Takeda T, Ichimura S. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis. J Orthop Sci. 2000;5(6):546-551.
  8. Iwamoto J, Takeda T, Sato Y, Yeh JK. Effect of vitamin K2 and growth hormone on the long bones in hypophysectomized young rats: a bone histomorphometry study. J Bone Miner Metab. 2007;25(1):46-53.
  9. Knapen MH, Schurgers LJ, Vermeer C. Vitamin K(2) supplementation improves hip bone geometry and bone strength indices in postmenopausal women. Osteoporos Int. Feb 8 2007.
  10. Koshihara Y, Hoshi K, Okawara R, Ishibashi H, Yamamoto S. Vitamin K stimulates osteoblastogenesis and inhibits osteoclastogenesis in human bone marrow cell culture. J Endocrinol. 2003;176(3):339-348.
  11. Nishiguchi S, Shimoi S, Kurooka H, et al. Randomized pilot trial of vitamin K2 for bone loss in patients with primary biliary cirrhosis. J Hepatol 2001;35:543-545.
  12. Plaza SM, Lamson DW. Vitamin K2 in bone metabolism and osteoporosis. Altern Med Rev. Mar 2005;10(1):24-35.
  13. Purwosunu Y, Rachman IA, Reksoprodjo S, Sekizawa A. Vitamin K2 treatment for postmenopausal osteoporosis in Indonesia. Journal of Obstetrics and Gynaecology Research. 2006;32(2):230-234.
  14. Sasaki N, Kusano E, Takahashi H, et al. Vitamin K2 inhibits glucocorticoid-induced bone loss partly by preventing the reduction of osteoprotegerin (OPG). J Bone Miner Metab. 2005;23(1):41-47.
  15. Sato Y, Honda Y, Kaji M, et al. Amelioration of osteoporosis by menatetrenone in elderly female Parkinson's disease patients with vitamin D deficiency. Bone 2002;31:114-118.
  16. Sato Y, Honda Y, Kaji M, et al. Amelioration of osteoporosis by menatetrenone in elderly female Parkinson's disease patients with vitamin D deficiency. Bone 2002;31:114-118.
  17. Sato Y, Honda Y, Kuno H, Oizumi K. Menatetrenone ameliorates osteopenia in disuse-affected limbs of vitamin D- and K-deficient stroke patients. Bone. Sep 1998;23(3):291-296.
  18. Shiomi S, Nishiguchi S, Kubo S, et al. Vitamin K2 (menatetrenone) for bone loss in patients with cirrhosis of the liver. The American Journal of Gastroenterology. 2002;97(4):978-981.
  19. Shiraki M, Shiraki Y, Aoki C, Miura M. Vitamin K2 (Menatetrenone) Effectively Prevents Fractures and Sustains Lumbar Bone Mineral Density in Osteoporosis. Journal of Bone and Mineral Research. 2000;15(3):515-522.
  20. Somekawa Y, Chigughi M, Harada M, Ishibashi T. Use of vitamin K2 (menatetrenone) and 1,25-dihydroxyvitamin D3 in the prevention of bone loss induced by leuprolide. J Clin Endocrinol Metab 1999;84:2700-2704.
  21. Sugiyama T, Tanaka H, Kawai S. Clinical vignette. Vitamin K plus vitamin D treatment of bone problems in a child with skeletal unloading. J Bone Miner Res 1999;14:1466-1467.
  22. Ushiroyama T, Ikeda A, Ueki M. Effect of continuous combined therapy with vitamin K2 and vitamin D3 on bone mineral density and coagulofibrinolysis function in postmenopausal women. Maturitas. 2002;41(3):211-221.
  23. Vermeer C, Jie KS, Knapen MH. Role of vitamin K in bone metabolism. Annu Rev Nutr. 1995;15:1-22
  24. Yonemura K, Fukasawa H, Fujigaki Y, Hishida A. Protective effect of vitamins K2 and D3 on prednisolone-induced loss of bone mineral density in the lumbar spine. Am J Kidney Dis 2004;43:53-60.
  25. Yonemura K, Kimura M, Miyaji T, Hishida A. Short-term effect of vitamin K administration on prednisolone-induced loss of bone mineral density in patients with chronic glomerulonephritis. Calcif Tissue Int 2000;66:123-128.

MK4 and Fracture Reduction

  1. Booth SL, Tucker KL, Chen H, et al. Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women. Am J Clin Nutr. 2000;71(5):1201-1208.
  2. Cockayne S, Adamson J, Lanham-New S, Shearer MJ, Gilbody S, Torgerson DJ. Vitamin K and the Prevention of Fractures: Systematic Review and Meta-analysis of Randomized Controlled Trials. Arch Intern Med. 2006;166(12):1256-1261.
  3. Kaneki M, Hosoi T, Ouchi Y, Orimo H. Pleiotropic actions of vitamin K: protector of bone health and beyond? Nutrition. 2006;22(7-8):845-852.
  4. Sato Y, Kanoko T, Satoh K, Iwamoto J. Menatetrenone and vitamin D2 with calcium supplements prevent nonvertebral fracture in elderly women with Alzheimer's disease. Bone. 2005;36(1):61-68.
  5. Shiraki M, Shiraki Y, Aoki C, Miura M. Vitamin K2 (Menatetrenone) Effectively Prevents Fractures and Sustains Lumbar Bone Mineral Density in Osteoporosis. Journal of Bone and Mineral Research. 2000;15(3):515-522.

MK4 Cardiovascular Health Citations

  1. Adams J, Pepping J. Vitamin K in the treatment and prevention of osteoporosis and arterial calcification. Am J Health Syst Pharm. 2005;62(15):1574-1581.
  2. Pizzorno L, Pizzorno J. Vitamin K: Beyond coagulation to uses in bone, vascular and anti-cancer metabolism. Integr Med. 2008;7(2):24-30.
  3. Ronden JE, Groenen-van Dooren MMCL, Hornstra G, Vermeer C. Modulation of arterial thrombosis tendency in rats by vitamin K and its side chains. Atherosclerosis. 1997;132(1):61-67.
  4. Schurgers LJ, Dissel PE, Spronk HM, et al. Role of vitamin K and vitamin K-dependent proteins in vascular calcification. Z Kardiol. 2001;90 Suppl 3:57-63.
  5. Spronk HMH, Soute BAM, Schurgers LJ, Thijssen HHW, De Mey JGR, Vermeer C. Tissue-Specific Utilization of Menaquinone-4 Results in the Prevention of Arterial Calcification in Warfarin-Treated Rats. Journal of Vascular Research. 11 2003;40(6):531-537.
  6. Wallin R, Schurgers L, Wajih N. Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification. Thrombosis Research. 2008;122(3):411-417.

MK4 Citations for Postmenopausal Women

  1. Iwamoto I, Kosha S, Noguchi S, et al. A longitudinal study of the effect of vitamin K2 on bone mineral density in postmenopausal women a comparative study with vitamin D3 and estrogen-progestin therapy. Maturitas 1999;31:161-164.
  2. Iwamoto J, Takeda T, Ichimura S. Combined treatment with vitamin K2 and bisphosphonate in postmenopausal women with osteoporosis. Yonsei Med J 2003;44:751-756.
  3. Iwamoto J, Takeda T, Ichimura S. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis. J Orthop Sci. 2000;5(6):546-551.
  4. Knapen MH, Schurgers LJ, Vermeer C. Vitamin K(2) supplementation improves hip bone geometry and bone strength indices in postmenopausal women. Osteoporos Int. Feb 8 2007.
  5. Purwosunu Y, Rachman IA, Reksoprodjo S, Sekizawa A. Vitamin K2 treatment for postmenopausal osteoporosis in Indonesia. Journal of Obstetrics and Gynaecology Research. 2006;32(2):230-234.
  6. Ushiroyama T, Ikeda A, Ueki M. Effect of continuous combined therapy with vitamin K2 and vitamin D3 on bone mineral density and coagulofibrinolysis function in postmenopausal women. Maturitas. 2002;41(3):211-221.

MK4 in People with Alzheimer Disease

  1. Sato Y, Kanoko T, Satoh K, Iwamoto J. Menatetrenone and vitamin D2 with calcium supplements prevent nonvertebral fracture in elderly women with Alzheimer's disease. Bone. 2005;36(1):61-68.

MK4 Safety Citations

  1. Asakura H, Myou S, Ontachi Y, et al. Vitamin K administration to elderly patients with osteoporosis induces no hemostatic activation, even in those with suspected vitamin K deficiency. Osteoporos Int. Dec 2001;12(12):996-1000.
  2. Green PH, Jabri B. Coeliac disease. Lancet. 2003;362(9381):383-391.
  3. Ronden JE, Groenen-van Dooren MMCL, Hornstra G, Vermeer C. Modulation of arterial thrombosis tendency in rats by vitamin K and its side chains. Atherosclerosis. 1997;132(1):61-67.
  4. Ushiroyama T, Ikeda A, Ueki M. Effect of continuous combined therapy with vitamin K2 and vitamin D3 on bone mineral density and coagulofibrinolysis function in postmenopausal women. Maturitas. 2002;41(3):211-221.

MK4 Citations for People with Primary Biliary Cirrhosis

  1. Nishiguchi S, Shimoi S, Kurooka H, et al. Randomized pilot trial of vitamin K2 for bone loss in patients with primary biliary cirrhosis. J Hepatol 2001;35:543-545.

MK4 Citations for People with Parkinson Disease

  1. Sato Y, Honda Y, Kaji M, et al. Amelioration of osteoporosis by menatetrenone in elderly female Parkinson's disease patients with vitamin D deficiency. Bone 2002;31:114-118.

MK4 Citations for People with Anorexia Nervosa

  1. Iketani T, Kiriike N, B. Stein M, et al. Effect of menatetrenone (vitamin K2) treatment on bone loss in patients with anorexia nervosa. Psychiatry Research. 2003;117(3):259-269.

MK4 Citations for People taking Prednisone

  1. Hara K, Kobayashi M, Akiyama Y. Vitamin K2 (menatetrenone) inhibits bone loss induced by prednisolone partly through enhancement of bone formation in rats. Bone. Nov 2002;31(5):575-581.
  2. Inoue T, Sugiyama T, Matsubara T, et al. Inverse correlation between the changes of lumbar bone mineral density and serum undercarboxylated osteocalcin after vitamin K2 (menatetrenone) treatment in children treated with glucocorticoid and alfacalcidol. Endocr J 2001;48:11-18.
  3. Sasaki N, Kusano E, Takahashi H, et al. Vitamin K2 inhibits glucocorticoid-induced bone loss partly by preventing the reduction of osteoprotegerin (OPG). J Bone Miner Metab. 2005;23(1):41-47.
  4. Yonemura K, Fukasawa H, Fujigaki Y, Hishida A. Protective effect of vitamins K2 and D3 on prednisolone-induced loss of bone mineral density in the lumbar spine. Am J Kidney Dis 2004;43:53-60.
  5. Yonemura K, Kimura M, Miyaji T, Hishida A. Short-term effect of vitamin K administration on prednisolone-induced loss of bone mineral density in patients with chronic glomerulonephritis. Calcif Tissue Int 2000;66:123-128.

MK4 Citations for People on Leuprolide

  1. Somekawa Y, Chigughi M, Harada M, Ishibashi T. Use of vitamin K2 (menatetrenone) and 1,25-dihydroxyvitamin D3 in the prevention of bone loss induced by leuprolide. J Clin Endocrinol Metab 1999;84:2700-2704.

MK4 Citations for People Who’ve Had Strokes

  1. Sato Y, Honda Y, Kuno H, Oizumi K. Menatetrenone ameliorates osteopenia in disuse-affected limbs of vitamin D- and K-deficient stroke patients. Bone. Sep 1998;23(3):291-296.

MK4 Citations in People with Cirrhosis of the Liver

  1. Shiomi S, Nishiguchi S, Kubo S, et al. Vitamin K2 (menatetrenone) for bone loss in patients with cirrhosis of the liver. The American Journal of Gastroenterology. 2002;97(4):978-981.

Calcium and Vitamin D Citations

  1. Anderson PH, Sawyer RK, May BK, O'Loughlin PD, Morris HA. 25-Hydroxyvitamin D requirement for maintaining skeletal health utilising a Sprague-Dawley rat model. The Journal of Steroid Biochemistry and Molecular Biology. 2007;103(3-5):592-595.
  2. Fairfield KM, Fletcher RH. Vitamins for Chronic Disease Prevention in Adults: Scientific Review. JAMA. 2002;287(23):3116-3126.
  3. Gallagher JC, Rapuri P, Smith L. Falls are associated with decreased renal function and insufficient calcitriol production by the kidney. The Journal of Steroid Biochemistry and Molecular Biology. 2007;103(3-5):610-613.
  4. Grant AM, Avenell A, Campbell MK, et al. Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet. 2005;365(9471):1621-1628.
  5. Jesudason D, Need AG, Horowitz M, O'Loughlin PD, Morris HA, Nordin BEC. Relationship between serum 25-hydroxyvitamin D and bone resorption markers in vitamin D insufficiency. Bone. 2002;31(5):626-630.
  6. Larsen ER, Mosekilde L, Foldspang A. Vitamin D and Calcium Supplementation Prevents Osteoporotic Fractures in Elderly Community Dwelling Residents: A Pragmatic Population-Based 3-Year Intervention Study. Journal of Bone and Mineral Research. 2004;19(3):370-378.
  7. Masterjohn C. Vitamin D toxicity redefined: vitamin K and the molecular mechanism. Med Hypotheses. 2007;68(5):1026-1034.

Celiac Disease and Osteoporosis

  1. Dewar DH, Ciclitira PJ. Clinical features and diagnosis of celiac disease. Gastroenterology. 2005;128(4, Supplement 1):S19-S24.
  2. Green PH. The many faces of celiac disease: Clinical presentation of celiac disease in the adult population. Gastroenterology. 2005;128(4, Supplement 1):S74-S78.
  3. Green PH, Jabri B. Coeliac disease. Lancet. 2003;362(9381):383-391.
  4. Hernandez L, Green PH. Extraintestinal manifestations of celiac disease. Curr Gastroenterol Rep. Oct 2006;8(5):383-389.
  5. Kemppainen T, Kroger H, Janatuinen E, et al. Osteoporosis in adult patients with celiac disease. Bone. 1999/3 1999;24(3):249-255.
  6. Richard J. Farrell CPK. Diagnosis of celiac sprue. American Journal of Gastroenterology. 2001;96(12):3237-3246.
  7. Rodrigo L. Celiac disease. World J Gastroenterol. Nov 7 2006;12(41):6585-6593.
  8. Stenson WF, Newberry R, Lorenz R, Baldus C, Civitelli R. Increased Prevalence of Celiac Disease and Need for Routine Screening Among Patients With Osteoporosis. Arch Intern Med. 2005;165(4):393-399.

All Bone Health Topics

NBI's major consideration is to make certain that every product it develops has a strong body of supporting basic- and clinical-research. While dietary supplements are not approved by the FDA to diagnose, treat or prevent a disease, calcium is important and approved by the FDA to reduce osteoporosis risk. Beyond that, our NBI philosophy is that an educated consumer is the best consumer. You should learn as much as you can about every aspect of your health and how you can improve it.

While your healthcare professional knows you best and can make the best recommendations for you, we at NBI hope that the topics listed below help you learn about yourself. Please share this research with your healthcare provider and listen to their advice. We at NBI wish you and yours a healthy and happy life.

Bone Health Monograph

Bone Support Dietary Supplements:
magnesium, calcium, vitamin D, vitamin K (MK4 vs. MK7), strontium, soy, boron

Calcium Supplements

Conventional Approaches to Bone Health

Frequently Asked Questions

How does your calcium supplement compare to Osteo-K?

Research Citations Supporting Osteo-K Ingredients

Strontium and Bone Health

Vitamin K and Bone Health

How does your calcium supplement compare? Click to view a chart comparing Osteo-K to other leading calcium supplements, such as Viactiv, Citracal, Bone-Up, Os-Cal and Caltrate.

Why Osteo-K™ Clobbers the Competition

How does your calcium supplement compare?

Based on recommended daily usage. 
   OSTEO-K Osteo-K Minis
VIACTIV
BONE-UP

OS-CAL

CALTRATE

Calcium

 1000 mg
(as calcium citrate)

400 mg
(as calcium dimalate)

1000 mg

1000 mg

1000 mg

1200 mg

Vitamin D3

 2000 IU

2000 IU

400 IU

1000 IU

400 IU

800 IU

Vitamin K2
(as MK4)

45 mg

45 mg

       

Vitamin K2
(as MK7)*

     

10 mcg


 

Vitamin K1**
(phylloquinone)

   

80 mcg

100 mcg


 

Magnesium

     

500 mg
(oxide)


 

Boron (mg)


 

3 mg


 

Fracture Reduction

 87%

87%

16%

16%

16%

16%

   


Fracture Reduction. Most dietary supplements contain ingredients that have never been shown to decrease fractures and inferior forms of ingredients that the body cannot absorb and use. Calcium and vitamin D have only been shown to decrease fractures by about 16%. However, research shows that when MK4 is added to an osteoporosis supplement it can decrease fractures by up to 87%. The other ingredients, such as MK7, magnesium and boron in osteoporosis supplements have never been shown to reduce fractures in human clinical trials. To learn more, read the Bone Health Supplements Monograph and watch the Osteo-K Webinar.

*MK7. Bone health supplements that use MK7 are using an ingredient that has never been shown in any clinical trial to reduce fractures. Additionally, while MK4 is naturally produced in the body, MK7 is not. Nonetheless, this inferior form of vitamin K2 is what most manufacturers put in their calcium supplements when they contain vitamin K2.

**Vitamin K1. Vitamin K1 is naturally found in green leafy vegetables. Research confirms that a diet high in green leafy vegetables may decrease fractures, but there are no clinical trials showing fracture reduction from taking a calcium supplement containing vitamin K1.

Oxide minerals. The "oxide" form of minerals, such as magnesium, is an inferior form of mineral. The body can only absorb 2% of the magnesium when it's in the oxide form. Even though it says you're getting 500 mg magnesium, your body can only absorb about 10 mg. The rest passes right through you and out your stool.



MitoForte
MitoForte
Supreme Multivitamin (without iron)
Supreme Multivitamin (without iron)
FerroSolve
FerroSolve
NattoPine
NattoPine



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Showing comments 1-10 of 13 (Next 10) Click Here to see all comments
1. Joan on 12/15/2013, said:

I am 73 years old & in good health. I started taking Osteo K in early 2013 because I am at risk for osteoporasis. Right off the bat my finger nails suddenly took on unbelievable strength and a much healthier appearance before the 1st bottle was totally consumed! Then in the fall of 2013 a new doctor recommended that I use another product ... just weeks after discontinuing Osteo K and switching to another product my fingernails began splitting, chipping and lost their luster! I quickly reordered Osteo K and again before the first bottle was consumed my nails had grown so fast that I had to visit the manicurist twice in less than 30 days. Over many decades I have tried various well known forms of calcium, however, never ever have my finger nails responded to any product until I began using NBI Osteo K. Stands to reason, in my mind that my bones are also responding!
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2. Chris on 3/11/2013, said:

I am 47 years old. I started using Osteo-K 2 years ago after a dexa scan result of -2.0. I had a dexa scan done again this week (3/2013) and my T-score is now -1. Wow! What an improvement, I am so happy! Thank you so much!!!
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3. Anonymous User on 6/2/2012, said:

I was diagnosed with osteoporosis in both hips and osteopenia in the spine. After taking Osteo-K for a couple weeks all the hip pain that I had was gone (I did not need any advil anymore). I feel like my old self again. I am excited to see what my next bone density test will show. And I am happy to say that I have had NO side effects.
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4. Anonymous User on 5/2/2012, said:

slow
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5. Anonymous User on 1/6/2011, said:

I have been using Osteo-K for 5 months now, and am elated as my bone density scan came back stablized. I will be writing a much longer testimonial about this product. In short I have had Osteoporosis for years - have had to have zometa fusions done in Boston - they made me so so sick. I also got very sick from other prescription products such as fosamax and boniva - this is truly an amazing break through for anyone who is suffering bone loss. My personal doctor is truly amazaed.
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6. Anonymous User on 8/25/2010, said:

In October of 2008, I was diagnosed with having borderline osterporosis. I didn't want to take prescription drugs and found Dr. Neustadt who suggested Osteo-K. This past May, 2010, I had another bone scan and learned my bone density had increased 6% which my doctor said was statistically significant. I'm elated and want more women to know about this. It's possible to treat our bones with no side effects!
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7. John on 5/26/2010, said:

About three years ago, I was diagnosed with osteoporosis with a 7% bone loss. I was prescribed Fosamax and oral calcium supplements and took both for several months. When I had my second bone scan, I was worse. I read about Osteo-K in Bottom Line and ordered my first bottle. The results over the past few months have been good for me. I have fingernails past the ends of my fingers for the first time in my life and can’t wait for my next scan to see the improvements to my bones! Thank you NBI!!!
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8. Karen on 2/17/2010, said:

inceased bmd better than Fosomax in a much shorter time)
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9. John on 9/14/2009, said:

I've been using Osteo-K for two or three months now. I don't recall in which publication I first read about the product. I've had one total hip replacement and one that probably should be replaced. Since using Osteo-K there seems to be much less pain in this and other joints even though this was not the primary reason for taking Osteo-K. Previously I was taking Actonel for osteoporosis and thin bones.
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10. Anonymous User on 8/27/2009, said:

I was placed on Boniva in September 2008. It always bothered my stomach. I persevered with it but started getting pains in my joints, legs neck hands and wrists, and knees. My exercise program disappeared as I became weaker. My knees had to be drained three times because fluid had built up to such an extent walking was a problem. I spoke to the doctor about stopping the Boniva since I was in great health before starting it! He didn't feel it was a problem. I went home and began a search for help online. It was there I found Save Our Bones, Dr.Neustadt, and OsteoK. In three months my health has gone back to pre-Boniva days. That drug was truly poison for me. Thanks so much for the research that you have done and the great alternatives you offer to keep us in better health than many of the highly advertised drugs that are pushed so hard by drug companies and many doctors. Osteo-K has become my body's best friend! --Alice, New Jersey
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