Each bottle of Osteo-K contains 180 vegetarian capsules, a month's supply. Simply take three capsules twice daily with food.
Now you have two Osteo-K choices. NBI's original Osteo-K formula and Osteo-K Minis, which less capsules and smaller capsules but the same powerful nutrients shown to grow stronger bones and for oncology support.
Need help deciding which Osteo-K is right for you? Read the Osteo-K Comparison Page.
Need help deciding which Osteo-K is right for you? Read the Osteo-K Comparison Page.
Osteo-K contains a 45 mg of MK4™, also called MK-4™, menaquinone-4 and menatetrenone. MK4 is a form of Vitamin K2. The Archives of Internal Medicine confirms that 45 mg of MK4™ daily can decrease the risk of vertebral fractures by 60%, hip fractures by 71% and all nonvertebral fractures by 81%.
SAFETY: From a large number of clinical trials using dosages in excess of 40 mg/day, there were no reports of side effects associated with any type of hypercoagulable (increased blood clotting) state. Both animal and clinical studies support the conclusion that MK4 has no dangerous effects on blood clotting. More than 6,000 people (view table summarizing these studies) with AML, MDS, osteoporosis, Parkinson disease, Alzheimer disease, hepatocellular carcinoma, liver failure, liver cirrhosis, myelofibrosis and kidney failure on hemodialysis have taken 45 mg daily (and higher doses) of MK4 for up to eight years without any serious side effects. However, it should be noted that the anticoagulant effect of warfarin, functioning by its interference with the clotting effect of vitamin K, can be offset with as little as 1 mg of vitamin K. If you are on anticoagulant therapy (e.g., taking warfarin), you should not take Osteo-K. For everyone else, Osteo-K is safe.
Calcium and vitamin D decrease how fast people lose bone minerals; however, MK4 in the amounts found in Osteo-K and Osteo-K Minis have been shown to actually increase bone mineral density and decrease fracture risk.
Don't be fooled by other bone health formulas that contain vitamin K. Only Osteo-K contains the amount and form used in clinical trials--45 milligrams (nearly all other formulas contain much smaller amounts, measured in micrograms, which can be hundreds of times less than what's in Osteo-K). And other products contain MK7, another form of vitamin K, but which has never been shown in clinical trials to reduce fractures. Only MK4 reduces fractures. MK4 (45 mg daily) is so effective that it's been an approved by the Ministry of Health in Japan since 1995 for the treatment of osteoporosis.
MK4 (45 mg/d) alone and in combination with vitamin D3 and calcium matches or exceeds the benefits in clinical trials of Fosamax, Actonel and Boniva without the dangerous side effects.
MK4 exerts a powerful influence on promoting bone health and is one of the most frequently prescribed nutrients in Japan for growing strong bones and decreasing fractures. MK4 is a fat soluble vitamin that is a coenzyme for a vitamin K-dependent carboxylase enzyme catalyzing the carboxylation of the amino acid, glutamic acid, resulting in its conversion to gamma-carboxyglutamic acid (Gla).
Although vitamin K-dependent gamma-carboxylation occurs only on specific glutamic acid residues in a small number of proteins, it is critical to the calcium-binding function of those proteins. Three vitamin-K dependent proteins have been isolated in bone. Osteocalcin is a protein synthesized by osteoblasts (bone forming cells). The synthesis of osteocalcin by osteoblasts is regulated by the active form of vitamin D, 1,25(OH)2D3 or calcitriol. The mineral-binding capacity of osteocalcin requires vitamin K-dependent gamma-carboxylation of three glutamic acid residues.
Matrix Gla protein (MGP) has been found in bone, cartilage, and soft tissue, including blood vessels. The results of animal studies suggest MGP prevents the calcification of soft tissue and cartilage, while facilitating normal bone growth and development.
Vitamin D3, the active form of vitamin D, is involved in many physiological processes. It increases calcium absorption, and has been shown in clinical trials alone and in combination with MK4 and calcium, to reduce fracture risk in osteoporosis.
Calcium is essential for bones and teeth, heart, nerves, muscles, and blood clotting. About 99% of the calcium in the body is found in bones and teeth, while the other 1% is found in the blood and soft tissue. Calcium supplementation has been shown in clinical trials to increase bone mineral density. Providing supplemental calcium is the standard of care for people with low bone mineral density.
Directions: Take three capsules twice daily with food.
More than forty citations support the ingredients in Osteo-K for bone and cardiovascular health.
In October of 2008, I was diagnosed with having borderline osteoporosis. I didn't want to take prescription drugs and found Dr. Neustadt who suggested Osteo-K. This past May, 2010, I had another bone scan and learned my bone density had increased 6% which my doctor said was statistically significant. I'm elated and want more women to know about this. It's possible to treat our bones with no side effects!
—Ris, Bozeman, MT
Am very pleased with this product--improved results on my bone density scan!
—Margarete, Marana, AZ
About three years ago, I was diagnosed with osteoporosis with a 7% bone loss. I was prescribed Fosamax and oral calcium supplements and took both for several months. When I had my second bone scan, I was worse. I read about Osteo-K in Bottom Line and ordered my first bottle. The results over the past few months have been good for me. I have fingernails past the ends of my fingers for the first time in my life and can't wait for my next scan to see the improvements to my bones! Thank you NBI!!!
—Karen, Mesa, AZ.
I was still working full time as an accountant at age 70, but it was becoming painful to bend down or even stand for short periods of time.
—Arlene, Elk Grove Village, IL
Osteo-K increased bone mineral density better than Fosamax in a much shorter time.
I've been using Osteo-K for two or three months now. I don't recall in which publication I first read about the product. I've had one total hip replacement and one that probably should be replaced. Since using Osteo-K there seems to be much less pain in this and other joints even though this was not the primary reason for taking Osteo-K. Previously I was taking Actonel for osteoporosis and thin bones.
I started using Osteo-K about eight months ago, in June 2009. Before using Osteo-K, I was experiencing extremely painful joints and was using several pain medications and thought I might end up in a wheel chair. I needed pain medications just to sleep at night. My rheumatologist prescribed alendronate (Fosamax) to increase my bone density.
After reading about Osteo-K and hearing and reading about various horror stories about Fosamax, I decided to 'fire' my rheumatologist and stopped taking the Fosamax and instead bought 13 bottles of Osteo-K 'to try.' In a matter of weeks after starting the Osteo-K, I experienced remarkable relief from the majority of symptoms, especially the hip and knee pain. I am scheduled to go in for my next bone density test around July of 2010. I believe that this test will validate everything I personally believe to be true about Osteo-K.
—Rosemary, Cottrellville Twp., MI
I was thrilled to get the results of my recent bone density scan, which showed definite improvement in bone minerals in both my back and hip.I just turned 52 years old and have a small frame. Osteoporosis runs in my family. I am a healthy eater,exercise regularly and vigorously, and do not smoke. I am allergic to dairy products so I get calcium from supplements.
Because I know I am prone to this condition and try to "do all the right things" I was somewhat surprised that my traditional physician diagnosed osteoporosis when I got my baseline DEXA scan two years ago at age 50. When I received this diagnosis I consulted you and sent you the test results to review. Weekly Actonel had been prescribed. You suggested that I supplement the Actonel with Osteo-K, which you had developed.
I have followed a regimen of daily Osteo-K and weekly Actonel for two years and will discuss alleviating the Actonel with my traditional physician. I intend to continue using Osteo-K and look forward to evidence of further improved bone minerals in my next bone density scan two years from now.
—Karen, McClean, VA
I wanted to let you know that a recent bone density came back surprisingly well. My doctor called it a "robust" result in fact. My AP Spine (L1-L4) had a BMD change of 12.7 vs previous result.
I believe these results changed because I began Osteo K about 3 months ago. I was taking Fosamax for 7 years and had changed over to Boniva this past year with minimal change until I added the Osteo K supplement. My results had not been like this since '03! I thought you would be excited to know.
—Karen, Westford, MA
I was placed on Boniva in Sept.2008. It always bothered my stomach. I persevered with it but started getting pains in my joints, legs neck hands and wrists, and knees. My exercise program disappeared as I became weaker. My knees had to be drained Three times because fluid had built up to such an extent walking was a problem. I spoke to the doctor about stopping the Boniva since I was in great health before starting it! He didn't feel it was a problem. I went home and began a search for help online. It was there I found Save Our Bones, Dr. Neustadt and Osteo-K. In three months my health has gone back to pre Boniva days. That drug was truly poison for me. Thanks so much for the research that you have done and the great alternatives you offer to keep us in better health than many of the highly advertised drugs that are pushed so hard by drug companies and many doctors. Osteo K has become my body's best friend! You may share my story. I hope many women find their way to you.
—Alice, Point Pleasant Beach, NJ
I have been a board certified Gynecologist and Obstetrician for more than twenty years. As a clinical instructor for Obstetrics and Gynecology at John's Hopkins University, I trained medical students. One of the most dangerous conditions I repeatedly encountered was osteoporosis.
Osteoporosis has reached epidemic proportions all over the world. It's clear from my experience and the literature that osteoporosis increases the risk of major disabilities and early death. People with osteoporosis, or those who are at risk for osteoporosis, need to be proactive in protecting and improving the health of their bones.
I reviewed the research on the health effects of 45 mg/day of MK4. I am extremely impressed with MK4's ability to decrease fracture risk by up to 81%; better than any osteoporosis medication I have ever prescribed. I recommend my patients take Osteo-K to protect their bones and prevent fractures. I also encourage other physicians to use Osteo-K.
—Mick Lifson, MD, voted "Baltimore's Best Gynecologist" by Baltimore Magazine in 2002 and 2007.
I was diagnosed with gluten intolerance three years ago, after suffering for nearly fifty years with gut symptoms, migraine headaches, joint pain and skin rashes. Over the last ten years I developed severe, debilitating bone pain in my spine and pelvis associated with osteoporosis. Every time I tried to stretch or exercise my pain increased. I felt inflamed all the time.
Bone pain associated with bone loss due to malabsorption is a symptom commonly associated with gluten intolerance. After researching the health benefits and bone-building effects of MK4, a form of vitamin K, I started taking Osteo-K. MK4 is a non-soy based form of vitamin K shown to build bone and decrease fracture risk. Three days after beginning Osteo-K my bone pain began to improve. After three months of Osteo-K my bone pain is gone and I am able to gently exercise and stretch without spine or pelvic pain afterwards!
I recommended Osteo-K to another woman suffering from gluten-intolerance with osteoporosis and pelvic bone pain. After taking Osteo-K for one month she reports a 70% improvement in her bone pain. She also told me that she is now taking a weekly dance class and having no pain afterwards.
One of the most common findings of gluten intolerance is loss of bone, even in children. Prevention is always so much simpler than treating disease. Osteo-K is one more tool to help prevent the development of osteoporosis from malabsorption. Children who are diagnosed with gluten intolerance would benefit from taking Osteo-K, along with a gluten free diet, to improve bone-building while they are growing. If you already have osteoporosis, Osteo-K can dramatically decrease your pain and risk of fractures.
—Eve Cohn, DC, MS, Norman, OK
Following a traumatic hemorrhage which filled my lungs and nearly destroyed my life, my condition was diagnosed as mylodysplasia. This was a disease which caused my bones to stop producing normal amounts of blood platelets, the clotting factor that prevents uncontrolled bleeding. My doctor said there was no known cure for this disease and did not expect me to survive.
The hospital chaplains gathered in my room to help prepare me and my family for my imminent death. By the grace of God, I did not die, but continued to survive for nine weeks in the hospital before they sent me home to die.
In spite of the prognosis, I continued to live in this critical condition for two years. My survival depended on a schedule of three blood platelet infusions a week and countless blood transfusions. I endured chemo therapy, experimental drug therapy, frequent hemorrhages, agonizing pain and nausea which weakened me to the point of having to use a wheel chair. Obviously, I was unable to keep my job.
Eventually, I decided to take responsibility for my own health and through my research, discovered that vitamin K provided a coagulating factor. When I asked my doctor about vitamin K, he said it would not help my condition. I made the decision to try it on my own. When I started taking vitamin K in low dosage amounts of 1,000 mcg, the number of weekly infusions decreased from three to two. This encouraged me to gradually increase the dosage of vitamin K to 5,000 mcg. As the dosage increased so did the time between infusions.
My most significant breakthrough came when I discovered Osteo-K Bone Support in 45,000 mcg. This nutritional product was so effective that I was able to stop all platelet infusions and blood transfusions.
As I write this account of my medical experience, I live a very normal life with renewed energy and actually go dancing every week. Osteo-K has restored my life.
—Paula Etrick, Longmont, CO
I am seventy-eight years old and grew up in Butte, Montana being active with my children, my husband's business and my community. I have seven grandchildren now and three live near me. I want to stay healthy to be able to do things with them and continue to drive my car and live independently. I have severe osteoporosis. Four years ago I fell and broke my hip and leg, then one year later I fell and broke my shoulder and arm. I had to have surgery to repair my leg, and underwent a long, painful recovery. Two years ago I discovered Osteo-K. I've taken Osteo-K every day now since then. I have fallen two more times while taking Osteo-K, but I didn't break any bones. The doctors were completely surprised. I give Osteo-K all the credit. Thank you for saving my bones and my life.
—Dolores, Bozeman, MT