Newsletter signup | Shipping Policy | Contact us | Shopping Cart (0)

Osteo-K FAQ: MK4 and Building Bone

More FAQ Topics


General Osteo-K Questions About osteoporosis
Who should I take Osteo-K Osteoporosis diagnosis
Osteo-K and the FDA Osteoporosis risks
How to take Osteo-K Medications and diseases that cause osteoporosis and fractures
Osteo-K, calcium and your other supplements Bone density scans and fracture risk
Osteo-K and drug interactions Osteoporosis treatments

MK4, bone building and fracture prevention

Calcium and osteoporosis

Q: Does Osteo-K contain MK4?
Yes. Osteo-K is the only osteoporosis supplement on the market that contains the amount of MK4 used in clinical trials plus calcium and vitamin D3.

Q: What is MK4 and how does it work?
MK4 is a form of vitamin K2 and the principle ingredient in Osteo-K. MK4 works by promoting bone health through the formation of bone collagen, the connective tissue in bone. Bone is a complex tissue comprised of minerals such as calcium and connective tissue (collagen). The minerals give bone its hardness and the collagen gives bone its flexibility.

Q: Has MK4 been shown to promote and maintain healthy bones?
Yes. In clinical trials MK4 has been shown to be an important nutrient for building bone. It can build bones and decrease the risk of vertebral fracture by 60%, hip fracture by 71% and all nonvertebral fractures by 81%. In fact, 45 mg/day of MK4 has been an approved treatment for osteoporosis in Japan since 1995.

In comparison, Fosamax only decreases vertebral fracture risk by about 45 percent, Actonel by about 50 percent and Boniva by 52 percent.

Why Osteo-K clobbers the competition: click to view a chart comparing Osteo-K to other leading calcium supplements, such as Viactiv, Citracal, Bone-Up, Os-Cal and Caltrate.

Q: Is MK4 a drug?
Not in the United States. MK4 has been an approved treatment for osteoporosis in Japan since 1995. However, in the United States MK4 is regulated by the US Food and Drug Administration (FDA) as a dietary supplement. It has not been approved by the FDA prevent osteoporosis or as an osteoporosis treatment.

Q: Is MK4 a fracture treatment?
No. MK4 is a bone support nutrient. It is not used in fracture treatment; however, research concludes that it may be helpful in speeding the recovery from fractures and preventing fractures.

Q: Will 45 mg of MK4 increase my risk of blood clots?
Vitamin K is important for healthy blood clotting. However, taking extra vitamin K does not increase your risk. Studies have shown that taking in excess of even 135 mg/day of MK4 does not increase blood clot risk. That’s because once the body has enough vitamin K for normal clotting, it cannot use more. NOTE: If you are taking warfarin (Coumadin) taking MK4 will increase your risk for blood clots because MK4 counteracts this medication.

Q: How does MK4 compare with MK7?
MK4 and MK7 are forms of vitamin K2. However, only MK4 has been shown in clinical trials to decrease fracture risk.

Q: How does MK4 compare with strontium?
MK4 has been shown to decrease fracture risk nearly twice as effectively as strontium irrespective of bone mineral density.

Q: Can MK4 decrease my risk for osteoporosis?
Multiple clinical trials have shown that 45 mg of MK4 taken daily with calcium and vitamin D can prevent bone loss and decrease the risk of osteoporosis.

Q: Are there any side effects of MK4?
Studies have shown that like all dietary supplements, MK4 in a very small percentage of people can cause headaches and gas and bloating, which stop when you stop the dietary supplement.

Q: Will my bone density improve if I take MK4?
Not significantly. Studies show that MK4 can reduce the rate of bone loss and in some cases improve bone mineral density. For example, significant improvements in bone mineral density were noted in clinical trials that compared people taking 45 mg per day of MK4 with calcium and vitamin D3 to people not taking MK4. But again, bone density only predicts 44% of elderly (65 years or older) women and 21% of elderly men who will get a fracture. Clinical trials show that taking 45 mg daily of MK4 plus calcium and Vitamin D decreases fracture risk independent of of bone mineral density.