Belly Rescue™
Belly Rescue’s probiotic blend has been carefully selected based on published clinical trials and basic research to support healthy digestion, skin, mood, immunity, blood sugar and insulin, cholesterol, weight management, liver function and inflammation. Belly Rescue is shelf stable, so it stores and travels easily. All species are verified using DNA fingerprint technology.
Shelf stable
DNA-verified species
Potent probiotic and prebiotic blend
Healthy Belly. Healthy Body.
The Benefits of Probiotics
Belly Rescue™
Belly Rescue’s probiotic blend has been carefully selected based on published clinical trials and basic research to support healthy digestion, skin, mood, immunity, blood sugar and insulin, cholesterol, weight management, liver function and inflammation. Belly Rescue is shelf stable, so it stores and travels easily. All species are verified using DNA fingerprint technology.
Shelf stable
DNA-verified species
Potent probiotic and prebiotic blend
Healthy Belly. Healthy Body.
The Benefits of Probiotics
Top 8 Benefits of Probiotics
Probiotics are healthy bacteria that are naturally part of the microbiome. While not all beneficial bacteria have the same effects, specific species have been shown to promote healthy digestion, skin, mood, immunity, blood sugar and insulin, weight management, cholesterol, liver function and inflammation. A 2020 review of probiotics concluded, “multi-strain dietary supplements are at an advantage over single microorganisms,” because combining strains expands the range of potential benefits.
*References
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Bonfrate L, Di Palo DM, Celano G, et al. Effects of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 in IBS patients. Eur J Clin Invest. 2020;50(3):e13201.
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Corr SC, Li Y, Riedel CU, O’Toole PW, Hill C, Gahan CGM. Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118. Proceedings of the National Academy of Sciences of the United States of America. 2007;104(18):7617-7621.
Crittenden RG, Martinez NR, Playne MJ. Synthesis and utilisation of folate by yoghurt starter cultures and probiotic bacteria. Int J Food Microbiol. 2003;80(3):217-222.
Gargari G, Taverniti V, Balzaretti S, et al. Consumption of a Bifidobacterium bifidum Strain for 4 Weeks Modulates Dominant Intestinal Bacterial Taxa and Fecal Butyrate in Healthy Adults. Appl Environ Microbiol. 2016;82(19):5850-5859.
Gomi A, Yamaji K, Watanabe O, et al. Bifidobacterium bifidum YIT 10347 fermented milk exerts beneficial effects on gastrointestinal discomfort and symptoms in healthy adults: A double-blind, randomized, placebo-controlled study. J Dairy Sci. 2018;101(6):4830-4841.
Grimm V, Radulovic K, Riedel CU. Colonization of C57BL/6 Mice by a Potential Probiotic Bifidobacterium bifidum Strain under Germ-Free and Specific Pathogen-Free Conditions and during Experimental Colitis. PLoS One. 2015;10(10):e0139935.
Guglielmetti S, Mora D, Gschwender M, Popp K. Randomised clinical trial: Bifidobacterium bifidum MIMBb75 significantly alleviates irritable bowel syndrome and improves quality of life–a double-blind, placebo-controlled study. Aliment Pharmacol Ther. 2011;33(10):1123-1132.
Hepburn NJ, Garaiova I, Williams EA, Michael DR, Plummer S. Probiotic supplement consumption alters cytokine production from peripheral blood mononuclear cells: a preliminary study using healthy individuals. Benef Microbes. 2013;4(4):313-317.
Imaoka A, Shima T, Kato K, et al. Anti-inflammatory activity of probiotic Bifidobacterium: enhancement of IL-10 production in peripheral blood mononuclear cells from ulcerative colitis patients and inhibition of IL-8 secretion in HT-29 cells. World J Gastroenterol. 2008;14(16):2511-2516.
Kajander K, Hatakka K, Poussa T, Färkkilä M, Korpela R. A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6-month intervention. Aliment Pharmacol Ther. 2005;22(5):387-394.
Khailova L, Dvorak K, Arganbright KM, et al. Bifidobacterium bifidum improves intestinal integrity in a rat model of necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2009;297(5):G940-949.
Khailova L, Mount Patrick SK, Arganbright KM, Halpern MD, Kinouchi T, Dvorak B. Bifidobacterium bifidum reduces apoptosis in the intestinal epithelium in necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2010;299(5):G1118-1127.
Kim CS, Cha L, Sim M, et al. Probiotic Supplementation Improves Cognitive Function and Mood with Changes in Gut Microbiota in Community-Dwelling Older Adults: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial. J Gerontol A Biol Sci Med Sci. 2021;76(1):32-40.
Lewis ED, Antony JM, Crowley DC, et al. Efficacy of Lactobacillus paracasei HA-196 and Bifidobacterium longum R0175 in Alleviating Symptoms of Irritable Bowel Syndrome (IBS): A Randomized, Placebo-Controlled Study. Nutrients. 2020;12(4).
Loman BR, Hernández-Saavedra D, An R, Rector RS. Prebiotic and probiotic treatment of nonalcoholic fatty liver disease: a systematic review and meta-analysis. Nutr Rev. 2018;76(11):822-839.
Ma Y-Y, Li L, Yu C-H, Shen Z, Chen L-H, Li Y-M. Effects of probiotics on nonalcoholic fatty liver disease: a meta-analysis. World journal of gastroenterology. 2013;19(40):6911-6918.
Macfarlane S, Cleary S, Bahrami B, Reynolds N, Macfarlane GT. Synbiotic consumption changes the metabolism and composition of the gut microbiota in older people and modifies inflammatory processes: a randomised, double-blind, placebo-controlled crossover study. Aliment Pharmacol Ther. 2013;38(7):804-816.
Marotta A, Sarno E, Del Casale A, et al. Effects of Probiotics on Cognitive Reactivity, Mood, and Sleep Quality. Frontiers in psychiatry. 2019;10:164-164.
N GA, EM MA, Shabanna S, Abd-Elrahman E. Protective Efficacy of Streptococcus Thermophilus Against Acute Cadmium Toxicity in Mice. Iran J Pharm Res. 2018;17(2):695-707.
Namba K, Hatano M, Yaeshima T, Takase M, Suzuki K. Effects of Bifidobacterium longum BB536 administration on influenza infection, influenza vaccine antibody titer, and cell-mediated immunity in the elderly. Biosci Biotechnol Biochem. 2010;74(5):939-945.
O’Mahony L, McCarthy J, Kelly P, et al. Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles. Gastroenterology. 2005;128(3):541-551.
Ouml, Zo, Ul F, et al. The Function of Lactic Acid Bacteria on Biogenic Amines Production by Food-Borne Pathogens in Arginine Decarboxylase Broth. Food Science and Technology Research. 2012;18(6):795-804.
Philippe D, Heupel E, Blum-Sperisen S, Riedel CU. Treatment with Bifidobacterium bifidum 17 partially protects mice from Th1-driven inflammation in a chemically induced model of colitis. Int J Food Microbiol. 2011;149(1):45-49.
Pinto-Sanchez MI, Hall GB, Ghajar K, et al. Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome. Gastroenterology. 2017;153(2):448-459.e448.
Pophaly SD, Poonam S, Pophaly SD, et al. Glutathione biosynthesis and activity of dependent enzymes in food-grade lactic acid bacteria harbouring multidomain bifunctional fusion gene (gshF). J Appl Microbiol. 2017;123(1):194-203.
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Rerksuppaphol S, Rerksuppaphol L. A Randomized Double-blind Controlled Trial of Lactobacillus acidophilus Plus Bifidobacterium bifidum versus Placebo in Patients with Hypercholesterolemia. J Clin Diagn Res. 2015;9(3):Kc01-04.
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Steenbergen L, Sellaro R, van Hemert S, Bosch JA, Colzato LS. A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood. Brain, Behavior, and Immunity. 2015;48:258-264.
Sybesma W, Starrenburg M, Tijsseling L, Hoefnagel MH, Hugenholtz J. Effects of cultivation conditions on folate production by lactic acid bacteria. Appl Environ Microbiol. 2003;69(8):4542-4548.
Tao Y-W, Gu Y-L, Mao X-Q, Zhang L, Pei Y-F. Effects of probiotics on type II diabetes mellitus: a meta-analysis. Journal of Translational Medicine. 2020;18(1):30.
Vitellio P, Celano G, Bonfrate L, Gobbetti M, Portincasa P, De Angelis M. Effects of Bifidobacterium longum and Lactobacillus rhamnosus on Gut Microbiota in Patients with Lactose Intolerance and Persisting Functional Gastrointestinal Symptoms: A Randomised, Double-Blind, Cross-Over Study. Nutrients. 2019;11(4).
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Wang Y. Glutathione biosynthesis is essential for antioxidant and anti-inflammatory effects of Streptococcus thermophilus. International dairy journal. 2019;v. 89:pp. 31-36-2019 v.2089.
Williams EA, Stimpson J, Wang D, et al. Clinical trial: a multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double-blind placebo-controlled study. Aliment Pharmacol Ther. 2009;29(1):97-103.
Yogeswara IBA, Maneerat S, Haltrich D. Glutamate Decarboxylase from Lactic Acid Bacteria-A Key Enzyme in GABA Synthesis. Microorganisms. 2020;8(12).
Yong SJ, Tong T, Chew J, Lim WL. Antidepressive Mechanisms of Probiotics and Their Therapeutic Potential. Front Neurosci. 2019;13:1361.
Yoon JS, Sohn W, Lee OY, et al. Effect of multispecies probiotics on irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. J Gastroenterol Hepatol. 2014;29(1):52-59.
Belly Rescue Frequently Asked Questions
General Questions
Q: Do I have to refrigerate Belly Rescue? No. Belly Rescue is shelf-stable so it stores and travels easily. Store the product in a cool, dry place out of direct sunlight.
Q: What are probiotics? Probiotics are healthy gut bacteria that provide many health benefits.
Q: What are prebiotics? Prebiotics are fiber that probiotics use as fuel to help them create their health benefits.
Q: Are probiotics safe? Research and many years of clinical use show that probiotics are safe; however, if you are immune-compromised or have other illnesses, check with your healthcare provider before taking probiotics.
Top Supplements for Healthy Skin
When it comes to skin damage, there are two major underlying causes. One is caused by decreased collagen production creating the typical lines and that comes with getting older. People who once felt young and vibrant feel uncomfortable when they see crow’s feet, elevens and drier, sagging skin staring back at them in the mirror. The other category of damage, which can contribute to acne, psoriasis, and atopic dermatitis, is caused by chronic inflammation. In this situation, healthy cell turnover is disrupted, creating skin damage, redness and irritation. Fortunately, natural approaches that promote skin health can help.
Top 8 Benefits of Probiotics
Your gut contains a mind-boggling amount of microorganisms. Probiotics in human intestines number in the trillions. Its collective genome contains at least 100 times as many genes as your genome, representing a total of 500-1000 species. The link between the gut microbiome and systemic health is irrefutable.
Probiotics are healthy bacteria that are naturally part of the microbiome. While not all beneficial bacteria have the same effects, specific species, have been shown to promote healthy mood, immune system, blood sugar control, and insulin, healthy weight, cholesterol, liver function, and support healing leaky gut.
How Probiotics Improve Your Nutrition
One surprising skill probiotics excel at is manufacturing nutrients, which they then release for us to absorb and use for our own needs. It’s like having a little dietary supplement factory in your gut producing vitamins, antioxidants, amino acids, healthy fats and other nutrients. This helps explain many of the probiotic health benefits researchers have discovered. It’s a true symbiotic relationship, where you give them a home and, in turn, they help you survive. Learn which probiotic species produce different nutrients and how they support optimal health.
Research Citations
Blood Sugar and Insulin Support
He J, Zhang F, Han Y. Effect of probiotics on lipid profiles and blood pressure in patients with type 2 diabetes: A meta-analysis of RCTs. Medicine (Baltimore). 2017;96(51):e9166.
Panwar H, Rashmi HM, Batish VK, Grover S. Probiotics as potential biotherapeutics in the management of type 2 diabetes – prospects and perspectives. Diabetes Metab Res Rev. 2013;29(2):103-112.
Tao Y-W, Gu Y-L, Mao X-Q, Zhang L, Pei Y-F. Effects of probiotics on type II diabetes mellitus: a meta-analysis. Journal of Translational Medicine. 2020;18(1):30.
Cardiovascular Support
Guo Z, Liu XM, Zhang QX, et al. Influence of consumption of probiotics on the plasma lipid profile: a meta-analysis of randomised controlled trials. Nutr Metab Cardiovasc Dis. 2011;21(11):844-850.
Rerksuppaphol S, Rerksuppaphol L. A Randomized Double-blind Controlled Trial of Lactobacillus acidophilus Plus Bifidobacterium bifidum versus Placebo in Patients with Hypercholesterolemia. J Clin Diagn Res. 2015;9(3):Kc01-04.
Xu F, Hu X-J, Singh W, Geng W, Tikhonova IG, Lin J. The complex structure of bile salt hydrolase from Lactobacillus salivarius reveals the structural basis of substrate specificity. Scientific Reports. 2019;9(1):12438.
Digestive Support (Gas, Bloating and Discomfort)
Li B, Liang L, Deng H, Guo J, Shu H, Zhang L. Efficacy and Safety of Probiotics in Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis. Front Pharmacol. 2020;11:332.
Skrzydło-Radomańska B, Prozorow-Król B, Cichoż-Lach H, et al. The Effectiveness and Safety of Multi-Strain Probiotic Preparation in Patients with Diarrhea-Predominant Irritable Bowel Syndrome: A Randomized Controlled Study. Nutrients. 2021;13(3).
Yoon JS, Sohn W, Lee OY, et al. Effect of multispecies probiotics on irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. J Gastroenterol Hepatol. 2014;29(1):52-59.
Skin Support
Fabbrocini G, Bertona M, Picazo Ó, Pareja-Galeano H, Monfrecola G, Emanuele E. Supplementation with Lactobacillus rhamnosus SP1 normalises skin expression of genes implicated in insulin signalling and improves adult acne. Benef Microbes. 2016;7(5):625-630.
Groeger D, O’Mahony L, Murphy EF, et al. Bifidobacterium infantis 35624 modulates host inflammatory processes beyond the gut. Gut Microbes. 2013;4(4):325-339.
Jung GW, Tse JE, Guiha I, Rao J. Prospective, randomized, open-label trial comparing the safety, efficacy, and tolerability of an acne treatment regimen with and without a probiotic supplement and minocycline in subjects with mild to moderate acne. J Cutan Med Surg. 2013;17(2):114-122.
Kim J, Ko Y, Park YK, Kim NI, Ha WK, Cho Y. Dietary effect of lactoferrin-enriched fermented milk on skin surface lipid and clinical improvement of acne vulgaris. Nutrition. 2010;26(9):902-909.
Lynn DD, Umari T, Dunnick CA, Dellavalle RP. The epidemiology of acne vulgaris in late adolescence. Adolesc Health Med Ther. 2016;7:13-25.
Navarro-Lopez V, Nunez-Delegido E, Ruzafa-Costas B, Sanchez-Pellicer P, Aguera-Santos J, Navarro-Moratalla L. Probiotics in the Therapeutic Arsenal of Dermatologists. Microorganisms. 2021;9(7).
Puch F, Samson-Villeger S, Guyonnet D, Blachon JL, Rawlings AV, Lassel T. Consumption of functional fermented milk containing borage oil, green tea and vitamin E enhances skin barrier function. Exp Dermatol. 2008;17(8):668-674.
Tuchayi SM, Makrantonaki E, Ganceviciene R, Dessinioti C, Feldman SR, Zouboulis CC. Acne vulgaris. Nature Reviews Disease Primers. 2015;1(1):15029.
Immune Support
Adeniyi BA, Adetoye A, Ayeni FA. Antibacterial activities of lactic acid bacteria isolated from cow faeces against potential enteric pathogens. Afr Health Sci. 2015;15(3):888-895.
Corr SC, Li Y, Riedel CU, O’Toole PW, Hill C, Gahan CGM. Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118. Proceedings of the National Academy of Sciences of the United States of America. 2007;104(18):7617-7621.
Fontaine L, Hols P. The inhibitory spectrum of thermophilin 9 from Streptococcus thermophilus LMD-9 depends on the production of multiple peptides and the activity of BlpG(St), a thiol-disulfide oxidase. Appl Environ Microbiol. 2008;74(4):1102-1110.
Gilbreth SE, Somkuti GA. Thermophilin 110: a bacteriocin of Streptococcus thermophilus ST110. Curr Microbiol. 2005;51(3):175-182.
Kabuki T, Uenishi H, Watanabe M, Seto Y, Nakajima H. Characterization of a bacteriocin, Thermophilin 1277, produced by Streptococcus thermophilus SBT1277. J Appl Microbiol. 2007;102(4):971-980.
Kolling GL, Wu M, Warren CA, et al. Lactic acid production by Streptococcus thermophilus alters Clostridium difficile infection and in vitro Toxin A production. Gut Microbes. 2012;3(6):523-529.
Lei WT, Shih PC, Liu SJ, Lin CY, Yeh TL. Effect of Probiotics and Prebiotics on Immune Response to Influenza Vaccination in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2017;9(11).
Plaza-Diaz J, Ruiz-Ojeda FJ, Gil-Campos M, Gil A. Mechanisms of Action of Probiotics. Advances in nutrition (Bethesda, Md). 2019;10(suppl_1):S49-S66.
Preidis GA, Weizman AV, Kashyap PC, Morgan RL. AGA Technical Review on the Role of Probiotics in the Management of Gastrointestinal Disorders. Gastroenterology. 2020;159(2):708-738.e704.
Rossi F, Marzotto M, Cremonese S, Rizzotti L, Torriani S. Diversity of Streptococcus thermophilus in bacteriocin production; inhibitory spectrum and occurrence of thermophilin genes. Food Microbiol. 2013;35(1):27-33.
Mood Support
Clemente JC, Ursell LK, Parfrey LW, Knight R. The impact of the gut microbiota on human health: an integrative view. Cell. 2012;148(6):1258-1270.
Foster JA, McVey Neufeld KA. Gut-brain axis: how the microbiome influences anxiety and depression. Trends Neurosci. 2013;36(5):305-312.
Marotta A, Sarno E, Del Casale A, et al. Effects of Probiotics on Cognitive Reactivity, Mood, and Sleep Quality. Frontiers in psychiatry. 2019;10:164-164.
Mörkl S, Butler MI, Holl A, Cryan JF, Dinan TG. Probiotics and the Microbiota-Gut-Brain Axis: Focus on Psychiatry. Curr Nutr Rep. 2020;9(3):171-182.
Ouml, Zo, Ul F, et al. The Function of Lactic Acid Bacteria on Biogenic Amines Production by Food-Borne Pathogens in Arginine Decarboxylase Broth. Food Science and Technology Research. 2012;18(6):795-804.
Schächtle MA, Rosshart SP. The Microbiota-Gut-Brain Axis in Health and Disease and Its Implications for Translational Research. Front Cell Neurosci. 2021;15:698172.
Sharifi-Rad J, Rodrigues CF, Stojanovic-Radic Z, et al. Probiotics: Versatile Bioactive Components in Promoting Human Health. Medicina (Kaunas). 2020;56(9).
Steenbergen L, Sellaro R, van Hemert S, Bosch JA, Colzato LS. A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood. Brain, Behavior, and Immunity. 2015;48:258-264.
Wu S-I, Wu C-C, Tsai P-J, et al. Psychobiotic Supplementation of PS128TM Improves Stress, Anxiety, and Insomnia in Highly Stressed Information Technology Specialists: A Pilot Study. Frontiers in Nutrition. 2021;8(130).
Yong SJ, Tong T, Chew J, Lim WL. Antidepressive Mechanisms of Probiotics and Their Therapeutic Potential. Front Neurosci. 2019;13:1361.
Liver Support
Loman BR, Hernández-Saavedra D, An R, Rector RS. Prebiotic and probiotic treatment of nonalcoholic fatty liver disease: a systematic review and meta-analysis. Nutr Rev. 2018;76(11):822-839.
Ma Y-Y, Li L, Yu C-H, Shen Z, Chen L-H, Li Y-M. Effects of probiotics on nonalcoholic fatty liver disease: a meta-analysis. World journal of gastroenterology. 2013;19(40):6911-6918.
Sofi F, Casini A. Mediterranean diet and non-alcoholic fatty liver disease: new therapeutic option around the corner? World J Gastroenterol. 2014;20(23):7339-7346.
Xie C, Halegoua-DeMarzio D. Role of Probiotics in Non-alcoholic Fatty Liver Disease: Does Gut Microbiota Matter? Nutrients. 2019;11(11).
Weight Management Support
Abenavoli L, Scarpellini E, Colica C, et al. Gut Microbiota and Obesity: A Role for Probiotics. Nutrients. 2019;11(11).
Cerdó T, García-Santos JA, G. Bermúdez M, Campoy C. The Role of Probiotics and Prebiotics in the Prevention and Treatment of Obesity. Nutrients. 2019;11(3):635.
Ley RE, Bäckhed F, Turnbaugh P, Lozupone CA, Knight RD, Gordon JI. Obesity alters gut microbial ecology. Proceedings of the National Academy of Sciences of the United States of America. 2005;102(31):11070-11075.