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Formulated by physicians from
Harvard, Cornell, MIT and Bastyr

Cardiovascular Support

Supporting healthy blood clotting within the normal range and healthy blood pressure are crucial for heart and blood vessel health. Blood clots account for 80% of strokes. Dangerous blood clotting can also cause painful situatons anywhere they occur, including the back of the legs in a situation called deep vein thrombosis (DVT). High blood pressure damages blood vessel walls and increase the risk for heart attacks and strokes. Conditions that increase your risk for dangerous blood clots or high blood pressure include smoking, sedentary lifestyle, diabetes, obesity, family history, cardiovascular disease and cancer.

NattoPine® contains a powerful combination of nattokinase and pine bark (Pinus massoniana) extract.Both of these nutrients have been extensively studied for their health benefits. Nattokinase supports healthy blood clotting within normal levels and promotes healthy circulation and blood pressure. Pine bark extract (Pinus massoniana) is rich in proanthocyanidins, which are strong quenchers of reactive oxygen species (ROS). Unhealthy levels of ROS are known to damage blood vessels and create inflammation. Pine bark extract helps protect from damaging free radicals to support heart and blood vessel health. With 182.5 mg (3650 fibrinolytic units) of nattokinase and 300 mg of pine bark extract per serving, NattoPine contains the highest dose combination of these nutrients for broad-spectrum cardiovascular support.

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Highest dose combination of nattokinase and pine bark extract
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Highest dose combination of nattokinase and pine bark extract
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182.5 mg nattokinase (3650 fibrinolytic units) and 300 mg pine bark extract per serving
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182.5 mg nattokinase (3650 fibrinolytic units) and 300 mg pine bark extract per serving
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Supports healthy blood clotting, blood pressure and circulation
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Supports healthy blood clotting, blood pressure and circulation

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How NattoPine Compares

*Footnotes

**Nattokinase is an extract from a Natto, a Japanese food from fermented soybeans. Nattokinase supports healthy blood clotting within normal levels and promotes healthy circulation and blood pressure.*

FU (fibrinolytic units) indicates the blood-clot dissolving strength of nattokinase. 

††Pine bark extract contains powerful antioxidants to support heart and blood vessel health.* 

*These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease.

NattoPine Formula Citations:
Cui Y, Xie H, Wang J. Potential biomedical properties of Pinus massoniana bark extract. Phytother Res. 2005;19(1):34-38.
Li YY, Feng J, Zhang XL, Cui YY. Pine bark extracts: nutraceutical, pharmacological, and toxicological evaluation. J Pharmacol Exp Ther. 2015;353(1):9-16.
Kim JY, Gum SN, Paik JK, et al. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens Res. 2008;31(8):1583-1588.
Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep. 2015;5:11601.
Weng Y, Yao J, Sparks S, Wang KY. Nattokinase. Int J Mol Sci. 2017;18(3):523.

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Surprising Links Between Anxiety and Heart Disease

Anxiety is emerging as a significant influence on cardiovascular disease. And that’s important because, in the U.S., one-quarter of all Americans suffer from an anxiety disorder at some point in their lives. And in turn, cardiovascular diseases continue to be the leading cause of illness and death in the United States.

Turmeric for a Healthy Heart

Turmeric for a Healthy Heart

Turmeric (Cucuma longa) is in the Zingiberaceae family, which also includes ginger (Zingiber oficinalis) and cardamom (Elettaria cardamomum). Humans tend to use the roots of members in this family as spices and for their health benefits. Turmeric has been used for...

Top Reasons to Take Nattokinase

Top Reasons to Take Nattokinase

Article at-a-glance: Nattokinase, an enzyme derived from the Japanese food natto, is a powerful support for optimal blood flow Nattokinase has been shown to mimic and enhance the activity of our own natural clot-dissolving enzyme, plasmin Optimal, healthy blood...

Research Citations

Nattokinase and Pine Bark Extract Citations

Cui Y, Xie H, Wang J. Potential biomedical properties of Pinus massoniana bark extract. Phytother Res. 2005;19(1):34-38.

Li YY, Feng J, Zhang XL, Cui YY. Pine bark extracts: nutraceutical, pharmacological, and toxicological evaluation. J Pharmacol Exp Ther. 2015;353(1):9-16.

Kim JY, Gum SN, Paik JK, et al. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens Res. 2008;31(8):1583-1588.

Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep. 2015;5:11601.

Weng Y, Yao J, Sparks S, Wang KY. Nattokinase. Int J Mol Sci. 2017;18(3):523.

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